Research

IPhoto Doctors looking through microscopen addition to specializing in patient care, faculty in the UF Department of Dermatology are actively engaged in on-going research programs. Our research in the treatment of the skin is propelling the department into the forefront of the dermatology research across the nation.  UF Dermatology is Global!

Clinical Trial Unit

Our goal is to enhance patient care by promoting understanding of skin diseases and supporting the development of ground breaking novel treatments.

 

Photo Dr. Anna DeBenedetto

 

 

 

 

 

Director: Anna De Benedetto, MD

Mary Bohannon

 

 

 

 

 

Clinical Coordinator: Mary Bohannan, CCRA

 

Ongoing clinical trials

Here you will find information about studies being conducted that require patient assistance.  If you are interested in participating please use the contact information provided on the flyer provided below:

Atopic Dermatitis

Skin Cancer

Basic Science Research

Research efforts at the University of Florida Department of Dermatology include several different areas, they are:

Atopic Dermatitis

by A. De Benedetto, MDR. Marsella, DVM, and D. Santoro, DVM, PhD

At the University of Florida, we established a unique collaboration between human and veterinary physicians to enhance our understanding on the pathogenesis of Atopic Dermatitis (also known as eczema), with the goal to translate our research findings in new treatment option for our patients (both people and animals).

Atopic dermatitis is characterized by skin barrier disruption, an aberrant adaptive immune response to environmental allergens (or antigen), susceptibility to cutaneous bacterial infections and intractable itch. Atopic dermatitis in dogs has striking similarities with the human counterpart both clinically and immunologically. As atopic dermatitis is a prevalent, chronic disease affecting 10-15% of children and up to 6% of adults in Westernized countries, studies to better understand the pathogenesis and identify new treatments have been in great demand.

Dr. De Benedetto’s research is focused on characterizing the cross talk between epidermal barrier structure and the immune system and their role in atopic dermatitis. The overriding hypothesis of her research is that repairing barrier defects may be effective in preventing and/or treating atopic dermatitis.  Dr. Marsella has developed an experimental model of atopic dermatitis in dogs at UF, which has been instrumental in studies on pathogenesis and studies to rapidly screen drugs with potential to be effective treatment options for both dogs and children. This model is unique in the world and represents a major improvement compared to the mouse model since dogs naturally develop atopic dermatitis and are genetically closer to humans than mice are. Dr. Santoro‘s research is mainly focused on the interaction between cutaneous innate immunity and cutaneous microflora. In particular, Dr. Santoro focuses on the role of antimicrobial peptides in the pathogenesis of skin infection in atopic dermatitis. The long-term goal of his research is to identify possible alterations in atopic keratinocytes to predispose to skin infections and atopic dermatitis.

The base of our truly translational research has been formed by clinically relevant questions and its motivated by the determination to take them to the bench and applying information acquired back to the clinics to improve treatments available to our patients (dogs and people).

The newly renovated state-of-art Comparative Dermatology laboratory is housed in the Small Animal Clinical Sciences – UF Veterinary College, in proximity of all UF core research facilities.

To become part of this study as a patient click here.

 

Pediatric Dermatology Research

My research focuses on the establishment and evolution of the infantile cutaneous microbiome and how it relates to the development of pediatric skin disease. It is likely that early priming of the cutaneous immune system is necessary to “teach” the immune system to tolerate commensal organisms.  As we understand more about what organisms are present early in infancy, and how these organisms prime the immune system, we will understand more about how to prevent or treat common pediatric skin diseases. Imagine a world where we are able to apply something to the skin in infancy to prevent the development of eczema!
At the University of Florida, we have assembled an interdisciplinary team with expertise in neonatology, microbiology, and epidemiology to investigate the impact of the microbiome on the development of skin disease. As one of only a few pediatric dermatologists in the state of Florida, my unique expertise in pediatric skin development and disease will allow translation of the basic science into impactful changes in clinical care.  ​

 

Keloids biology

by Dr. Vladimir Vincek

 

Molecular friendly tissue processing

by Dr. Vladimir Vincek